[4주차-2] Methods of Cognitive Neuroscience 2: A quantitative comparison of NIRS and fMRI across multiple cognitive tasks
4학기/인지신경과학 2011. 3. 24. 14:28A quantitative comparison of NIRS and fMRI across multiple cognitive tasks.
A quantitative comparison of NIRS and fMRI across multiple cognitive tasks
Abstract
연구 내용 자체로는 빵점. 이지만 세부적인 측정을 했기 때문에 의의가 있음.
Xu Cui, Signe Bray, Daniel M Bryant, Gary H Glover, Allan L Reiss (2011)
NeuroImage 54 (4) p. 2808-21
Abstract
Near infrared spectroscopy (NIRS) is ans increasingly popular technology for studying brain function. NIRS presents several advantages relative to functional magnetic resonance imaging(fMRI), such as measurement of concentration changes in both oxygenated and deoxygenated hemoglobin, finer temporal resolution, and ease of administration, as well as disadvantages, most prominently inferior spatial resolution and decreased signal-to-noise ratio (SNR). While fMRI has become the gold standard for in vivo imaging of the human brain, in practice NIRS is a more convenient and less expensive technology than fMRI. It is therefore of interest to many researchers how NIRS compares to fMRI in studies of brain function. in the present study we scanned participants with simultaneous NIRS and fMRI on a battery of cognitive tasks, placing NIRS probes over both frontal and parietal brain regions. We performed detailed comparisons of the signals in both temporal and spatial domains. We found that NIRS signals have significantly weaker SNR, but are nonetheless often highly correalted with fMRI measurements. Both SNR and the distance between the scalp and the brain contributed to variability in the NIRS/fMRI correlations. In the spatial domain, we found that a photon path forming an ellipse between the NIRS emitter and detector correlated most strongly with the BOLD response. Taken together these findings suggest that, while NIRS can be an appropriate substitute for fMIR for studying brain activity related to cognitive tasks, care should be taken when designing studies with NIRS to ensure that: 1) the spatial resolution is adequate for answering the question of interest and 2) the design accounts for weaker SNR, especially in brain regions more distal from the scalp
- NIRS
- 단점: SNR이 굉장히 낮고, 노이즈가 많고, 공간 해상도가 fMRI에 비해서 낮음.
fMRI
- 장점: 해상도가 높다
- 단점: 비싸고, 적용 task가 한정적이다.
fMRI는 MRI와는 다른데, MRI의 방법을 그대로 적용 할 수 있는지의 논쟁이 남아 있음
fMRI를 맹신하면 안되고, NIRS와 fMRI를 같이 측정하는 것은 좋다(저자의 입장).
fMRI 데이터 수집
- 특정 이벤트에 맞춘게 아니라 그 블럭의 크기에 맞춰서 수행
Methods - Participants
- Experimental procedure
- Task descriptions
- NIRS data acquisition
- fMRI data acquisition
- Identifying the channel locations
- Scalp–brain distance
- Temporal analysis
- Spatial analysis
- General linear model (GLM)-based analysis in each modality
연구 내용 자체로는 빵점. 이지만 세부적인 측정을 했기 때문에 의의가 있음.
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